VIP 10 mg

VIP 10 mg — a neuropeptide operating at the immune-nervous interface
Vasoactive Intestinal Peptide was named for where it was found, not for what it does. Its research profile now spans neuroprotection, immune regulation and circadian biology.

What is VIP?

VIP is a 28 amino acid neuropeptide belonging to the secretin-glucagon superfamily, acting through the VPAC1 and VPAC2 G protein-coupled receptors. Although originally isolated from intestinal tissue, it is now understood as a broadly distributed signalling molecule present throughout the central and peripheral nervous systems. Research interest centres on its unusual dual character: it functions simultaneously as a neurotransmitter and as an immunoregulatory signal, and it is additionally studied as a key coupling factor within the suprachiasmatic nucleus, the body's central circadian pacemaker.

Research interest

• VPAC1 / VPAC2 receptor signalling — used as the endogenous agonist standard in studies of these class B GPCRs.
• Neuroimmune regulation — investigated in research examining how a single peptide bridges nervous and immune signalling.
• Inflammatory pathway modulation — of interest to researchers studying cytokine expression and macrophage behaviour in preclinical models.
• Circadian biology — referenced in literature on suprachiasmatic nucleus neuronal synchronisation.
• Neuroprotection research — examined in preclinical contexts concerned with neuronal survival signalling.

VIP is relatively long for a neuropeptide and its helical conformation contributes to receptor engagement, making it sensitive to both proteolysis and conformational disruption. Purity and careful cold handling directly determine whether receptor assays behave as the literature predicts.

Specifications

• Content: 10 mg of active peptide per vial
• Form: Lyophilised powder (vial)
• Purity: Pharmaceutical-grade, batch-tested and lot-traceable
• Presentation: Sealed, tamper-evident single vial
• Storage: -20 °C sealed; 2-8 °C short-term

Handling & storage

Lyophilised material is best held at -20 °C in the sealed, unopened vial. Refrigeration at 2-8 °C is acceptable for short-term handling. Protect from light, humidity and repeated freeze-thaw exposure. Keep sealed, dry and frozen, away from light. Equilibrate the vial to room temperature before opening. Reconstitution should follow the facility's validated procedure using an appropriate sterile diluent; aliquot the solution, refrigerate it and avoid repeated freeze-thaw, to which longer neuropeptides are notably susceptible.

Why researchers buy from Rogue

• Batch-tested, not batch-guessed — purity and identity verified before a vial is ever listed.
• Authentic European sourcing — a short, controlled supply chain with sealed, tamper-evident vials.
• Consistency across orders — lot-to-lot control so repeat work stays comparable.
• Fast, tracked, discreet — quick EU-wide dispatch in unmarked packaging.

For research purposes only. Not a medicinal product. Not for human or veterinary consumption. Intended for qualified laboratory research use only. No statement on this page is a medical claim, and no administration, dosing or protocol guidance is offered or implied.

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