TB-500

TB-500 5 mg — the actin-binding fragment at the centre of cell migration research.
TB-500 is the synthetic peptide that isolates the functional core of thymosin beta-4, and it has become one of the standard tools for studying how cells physically move. Supplied as a 5 mg lyophilised vial, batch-tested and sealed for laboratory use.

What is TB-500?

TB-500 is a synthetic peptide corresponding to the actin-binding region of thymosin beta-4, one of the most abundant Proteins in mammalian cells and the principal sequestering agent for monomeric G-actin. The parent protein's activity is concentrated in a short motif, and TB-500 reproduces that motif in a compact, synthetically accessible form. By influencing the balance between monomeric and filamentous actin, it provides researchers with a defined probe into cytoskeletal dynamics — the machinery underlying cell migration, wound closure in culture models and vascular sprouting. Its small size and high solubility make it considerably easier to work with than the full-length protein.

Research interest

• Actin dynamics — a reference probe for G-actin sequestration and filament turnover.
• Cell migration — investigated in scratch-assay and chemotaxis models of directed motility.
• Tissue regeneration research — studied in preclinical models of soft tissue and wound repair.
• Angiogenesis — of interest to researchers examining endothelial sprouting and vessel formation.
• Cytoskeletal signalling — applied in work linking structural remodelling to downstream cell behaviour.

Specifications

• Content: 5 mg of active peptide per vial
• Form: Lyophilised powder (sealed vial)
• Purity: Pharmaceutical-grade, batch-tested
• Storage: 2–8 °C sealed and dry; −20 °C for long-term, protected from light

Handling & storage

TB-500 is highly water-soluble and generally well behaved, but the lyophilised cake is hygroscopic and should be protected from ambient moisture. Keep the vial sealed and refrigerated, and let it equilibrate to room temperature before opening so that condensation does not form on the powder. Reconstitution should follow the receiving laboratory's validated protocol: add solvent gently down the vial wall, swirl until clear and avoid vortexing or generating foam. Aliquot in low-binding tubes to limit adsorptive loss, store frozen and protected from light, and thaw each aliquot once. Discard any solution showing turbidity or particulates rather than filtering and reusing it.

Why source from Rogue

• Verified purity — every batch is traceable, analytically tested and released against its own certificate.
• European supply chain — sealed, authentic vials, shipped from within the EU and never sourced grey-market.
• Discreet, tracked delivery — fast dispatch across Europe in protective packaging, tracked end to end.

For research purposes only. Not a medicinal product. Not for human or veterinary consumption. Intended for qualified laboratory research use only.

Related: Peptides · CJC-1295 no DAC 5 mg · Semax