Sermorelin Acetate

Sermorelin Acetate 2 mg — the native GHRH fragment, and the field's baseline reference.
Sermorelin is the unmodified biologically active fragment of growth hormone-releasing hormone, which makes it the natural comparator for every engineered GHRH analogue that followed. Supplied as a 2 mg lyophilised vial, batch-tested and sealed.

What is Sermorelin Acetate?

Sermorelin acetate is a synthetic 29-amino-acid peptide corresponding to GHRH(1-29), the N-terminal fragment that carries essentially the full biological activity of the 44-residue native hormone. Supplied as the acetate salt for handling and solubility, it acts at the GHRH receptor on pituitary somatotrophs. Unlike stabilised analogues such as modified GRF(1-29), sermorelin carries no protective substitutions, so it is rapidly cleaved by dipeptidyl peptidase activity — a short, sharp exposure profile. For researchers, that is a feature rather than a limitation: it is the unmodified reference against which engineered stability is measured.

Research interest

• GHRH receptor pharmacology — the native-sequence agonist used to characterise receptor response.
• Somatotroph function — investigated in pituitary cell models examining GH synthesis and release.
• GH pulsatility — studied for episodic rather than sustained receptor stimulation.
• Analogue benchmarking — of interest to researchers comparing engineered GHRH variants against the parent fragment.
• Peptide degradation kinetics — a reference substrate in enzymatic stability and protease-resistance studies.

Specifications

• Content: 2 mg of active substance per vial
• Form: Lyophilised powder (sealed vial)
• Purity: Pharmaceutical-grade, batch-tested
• Storage: Sealed at 2–8 °C; −20 °C for long-term storage, dry and away from light

Handling & storage

A 29-residue unmodified peptide at a 2 mg fill demands careful technique on two fronts: recovery and stability. Equilibrate the sealed vial to ambient temperature before opening so moisture does not reach the small lyophilised cake, then reconstitute under your validated protocol with solvent directed down the vial wall so the entire inner surface is rinsed. Swirl gently; do not vortex, as shear promotes aggregation in longer chains. Because sermorelin lacks protease-resistant substitutions, reconstituted material is comparatively short-lived — hold it cold, protected from light, in low-binding single-use aliquots, and avoid freeze–thaw cycling entirely.

Why source from Rogue

• Verified purity — batch-tested material with documented identity and assay results.
• European supply chain — factory-sealed vials held in controlled conditions, never repackaged or grey-market.
• Discreet, tracked delivery — rapid EU-wide dispatch in unbranded, protective outer packaging.

For research purposes only. Not a medicinal product. Not for human or veterinary consumption. Intended for qualified laboratory research use only.

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