AOD-9604 5 mg

AOD-9604 5 mg — the growth hormone fragment stripped down to its metabolic core.
AOD-9604 is a fascinating piece of peptide engineering: a short fragment of human growth hormone that retains interest in lipid metabolism research while lacking the full hormone's broader activity profile. That separation of function is exactly what makes it a valuable research tool. Supplied as a 5 mg lyophilised vial.

What is AOD-9604?

AOD-9604 (anti-obesity drug 9604) is a modified analogue of the C-terminal region of human growth hormone, corresponding to residues 176–191 with an added tyrosine. Research on the parent hormone indicated that its lipolytic and its growth-promoting activities reside in different regions of the molecule; AOD-9604 was designed to isolate the former. Because the fragment does not carry the receptor-binding architecture of intact hGH, it is studied as a means of interrogating fat metabolism pathways without the confounding endocrine effects of the whole hormone — a clean dissection tool rather than a blunt instrument.

Research interest

• Lipolysis pathways — investigated in adipocyte models examining triglyceride breakdown mechanisms.
• Lipogenesis regulation — studied for its role in fat-storage signalling in preclinical systems.
• Structure–function dissection of hGH — a reference fragment for separating metabolic from somatogenic activity.
• Body composition models — of interest to researchers examining energy partitioning and adipose tissue biology.
• Fragment-based peptide design — a worked example of functional-domain isolation in hormone research.

Specifications

• Content: 5 mg of active substance per vial
• Form: Lyophilised powder (sealed vial)
• Purity: Pharmaceutical-grade, batch-tested
• Storage: Sealed at 2–8 °C; −20 °C long-term, dry and away from light

Handling & storage

Keep the vial sealed, refrigerated and dry until the moment of use, and allow it to equilibrate to ambient temperature before the stopper is broken so that condensation does not settle onto the hygroscopic cake. Reconstitution should be performed under the receiving laboratory's own validated protocol: introduce solvent slowly down the inside wall of the vial, avoid directing the stream onto the cake, and swirl gently until fully dissolved rather than vortexing. Peptide solutions adsorb onto ordinary plastic surfaces, so use low-binding tubes and tips for aliquoting. Store aliquots frozen, protected from light, and thaw each once only — repeated freeze–thaw cycling is the most common avoidable cause of assay variability.

AOD-9604 in depth: history, evidence and how it compares

Few research peptides have a paper trail like AOD-9604. It grew out of growth hormone research at Monash University in Melbourne and was developed by the Australian company Metabolic Pharmaceuticals as a candidate anti-obesity medicine. Early studies in obese mice reported more fat breakdown and less new fat formation, without the growth-promoting activity of the full hormone, and the fragment was reported not to raise IGF-1 the way intact growth hormone does.

The clinical story was less convincing. AOD-9604 went through several human trials during the 2000s, but the largest of them did not show a meaningful difference in weight loss compared with placebo, and development as an obesity drug was stopped. Later work turned to narrower preclinical questions, including animal models of osteoarthritis. AOD-9604 has never been authorised as a medicine in the EU, and growth hormone fragments such as AOD-9604 are named on the WADA Prohibited List, which matters to anyone competing in tested sport.

Peptides studied for appetite and satiety through the GLP-1 receptor belong to a different class altogether; our guide to semaglutide, tirzepatide and retatrutide explains how they work.

Realistic expectations follow from that record: AOD-9604 is a well-characterised research tool, not a proven slimming treatment. Rogue gives no usage or dosing advice, and any question about personal use, dose or duration belongs with a doctor. Rogue's peptides are sold for research purposes only and are not for human consumption.

Frequently asked questions

Is AOD-9604 the same as HGH Frag 176-191?

They are close relatives, not twins. Both are taken from the tail end of the growth hormone chain, but AOD-9604 is a modified version, and it is the one that was taken into human trials. The HGH Frag 176-191 research peptide is the unmodified sequence, used mainly in preclinical lipolysis and structure–function work. Neither is a whole growth hormone, and neither works like a GLP-1 drug.

Where can I buy AOD-9604 online in Europe?

Rogue ships AOD-9604 5 mg across the EU from EU stock, so your order does not have to clear customs on its way in from outside Europe. Every parcel is tracked and sent in plain, discreet packaging, and shipping is free on orders over €30. If you need several vials, multi-buy discounts apply automatically from 3 units; the full price ladder is shown on this page.

Can I get AOD-9604 from a pharmacy or on prescription?

No. AOD-9604 has never been authorised as a medicine in the EU, so pharmacies do not stock it and there is no licensed product for a doctor to prescribe. It is sold as a research compound. The rules on buying and holding research peptides differ from one country to another, so check what applies where you live before you order.

How can I tell whether an AOD-9604 vial is genuine?

Start with the basics: an intact seal, a clear label with product name, content and lot number, and a seller who can link that lot to a batch analysis, ideally HPLC for purity and mass spectrometry for identity. The contents should be a dry white cake or powder, never damp, sticky or discoloured. Treat prices far below the market with suspicion, because clean peptide synthesis has a real cost.

Does AOD-9604 really work for fat loss?

The evidence is mixed. Animal studies reported more fat breakdown and less fat storage, but the largest human trial found no meaningful difference in weight loss compared with placebo. Experience reports online are anecdotal and impossible to verify. Rogue supplies AOD-9604 for laboratory research, not as a slimming product, and any question about personal use belongs with a doctor.

How do I pay, and how is my order shipped?

You can pay by SEPA bank transfer or through a secure card payment link. Once your payment has been received, the order is dispatched from EU stock with a tracking number, so you can follow the parcel all the way to your door. Delivery time depends on the destination country, and the tracking page shows every step.

Why source from Rogue

• Verified purity — independent batch analysis on every lot we release, with traceability back to source.
• European supply chain — authentic, sealed stock warehoused and shipped inside the EU.
• Discreet, tracked delivery — plain, protected packaging and full tracking from our door to the lab bench.

For research purposes only. Not a medicinal product. Not for human or veterinary consumption. Intended for qualified laboratory research use only.

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