Kisspeptin-10 5 mg

Kisspeptin-10 5 mg — the upstream switch of the reproductive axis
Kisspeptin sits higher in the hormonal hierarchy than almost anything else researchers can probe. It acts before GnRH, before LH, before the gonads — which is why it reshaped reproductive neuroendocrinology.

What is Kisspeptin-10?

Kisspeptin-10 is the ten amino acid active fragment of the kisspeptin family, the shortest sequence that retains full agonist activity at the KISS1R (GPR54) receptor. Its discovery was a genuine turning point in neuroendocrinology: kisspeptin signalling was identified as an essential upstream gatekeeper of GnRH neuron activity, meaning it sits at the very top of the hypothalamic-pituitary-gonadal cascade. Researchers use it precisely because it allows the axis to be interrogated at its origin rather than downstream.

Research interest

• KISS1R / GPR54 signalling — used as a standard agonist in receptor pharmacology and neuronal signalling studies.
• GnRH neuron regulation — investigated in research examining how kisspeptin governs pulsatile GnRH output.
• Reproductive neuroendocrinology — a central tool compound in studies of pubertal onset and HPG-axis initiation in preclinical models.
• Metabolic-reproductive crosstalk — of interest to researchers exploring how energy status feeds into reproductive signalling.
• Fragment activity mapping — referenced in literature comparing kisspeptin-10, -13, -14 and -54 for relative potency and stability.

Short neuropeptides such as this are sensitive to oxidation and enzymatic fragmentation, and assay sensitivity at receptor Level is high enough that impurity artefacts are easily mistaken for signal. Verified, lot-traceable material is the only defensible starting point.

Specifications

• Content: 5 mg of active substance per vial
• Form: Lyophilised powder (vial)
• Purity: Pharmaceutical-grade, batch-tested and lot-traceable
• Presentation: Sealed, tamper-evident single vial
• Storage: -20 °C sealed; 2-8 °C short-term

Handling & storage

Keep the sealed vial frozen at -20 °C for extended storage, or at 2-8 °C for short-term laboratory handling. Avoid direct light, moisture ingress and repeated warming and cooling cycles. Store sealed and frozen, away from light and moisture. Equilibrate to ambient temperature before breaking the seal. Any laboratory reconstitution should use an appropriate sterile diluent per the facility's validated method; aliquot solutions to avoid repeated freeze-thaw, to which short neuropeptides are especially vulnerable.

Why source from Rogue

• Verified purity — every batch is identity- and purity-tested, with documentation traceable back to the production lot.
• European supply chain — sealed vials, authenticated manufacturing, never grey-market repackaging.
• Cold-aware logistics — protective packaging and fast, tracked dispatch across the EU.
• Discreet handling — plain outer packaging and full order confidentiality, from checkout to doorstep.

For research purposes only. Not a medicinal product. Not for human or veterinary consumption. Intended for qualified laboratory research use only. No statement on this page is a medical claim, and no administration, dosing or protocol guidance is offered or implied.

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