5-amino-1MQ 50mg

5-Amino-1MQ 50 mg — a small-molecule NNMT inhibitor for metabolic research.
5-Amino-1MQ has become one of the more interesting entries in the metabolic research toolkit: a small, cell-permeable molecule that targets an enzyme sitting directly at the junction of NAD+ metabolism and methylation balance. Supplied as a high-content 50 mg vial.

What is 5-Amino-1MQ?

5-Amino-1-methylquinolinium (5-amino-1MQ) is a small-molecule quinolinium compound — not a peptide — studied as an inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT consumes nicotinamide and the universal methyl donor S-adenosylmethionine, producing 1-methylnicotinamide. Because nicotinamide is a salvage-pathway precursor for NAD+, and because SAM governs cellular methylation capacity, NNMT activity influences two fundamental metabolic currencies at once. Its expression is notably high in adipose tissue and liver, which is why 5-amino-1MQ has become a standard probe for laboratories examining adipocyte energy handling and NAD+ pool dynamics.

Research interest

• NNMT inhibition — the reference small-molecule probe for interrogating this methyltransferase in cell models.
• NAD+ salvage metabolism — investigated for its influence on intracellular nicotinamide and NAD+ pools.
• Adipocyte biology — studied in fat cell models examining energy expenditure and lipid handling.
• Methylation balance — of interest to researchers examining SAM consumption and epigenetic methyl-donor availability.
• Body composition models — applied in preclinical work on metabolic rate and substrate partitioning.

Specifications

• Content: 50 mg of active substance per vial
• Form: Lyophilised powder (sealed vial)
• Purity: Pharmaceutical-grade, batch-tested
• Storage: Sealed, dry and dark at room temperature or refrigerated; −20 °C for long-term stocks

Handling & storage

Small quinolinium salts are hygroscopic and readily pick up atmospheric water, which complicates accurate gravimetric work. Keep the vial tightly sealed with a desiccant where possible, and let it equilibrate to ambient temperature before opening so moisture does not condense onto the powder. Weigh promptly and reseal. Reconstitution should follow the receiving laboratory's validated method and the solvent system appropriate to the assay; confirm complete dissolution and a clear solution before use. For a 50 mg fill spread across many experiments, prepare a concentrated stock, aliquot into single-use volumes and store frozen and protected from light rather than repeatedly opening and thawing a master stock.

Why source from Rogue

• Verified purity — every batch is traceable, analytically tested and released against its own certificate.
• European supply chain — sealed, authentic vials, shipped from within the EU and never sourced grey-market.
• Discreet, tracked delivery — fast dispatch across Europe in protective packaging, tracked end to end.

For research purposes only. Not a medicinal product. Not for human or veterinary consumption. Intended for qualified laboratory research use only.

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