MOTS-c 10 mg

MOTS-c 10 mg — a peptide written in mitochondrial DNA
Most Peptides are encoded in the nucleus. MOTS-c is not. It is transcribed from the mitochondrial genome itself, and that origin makes it one of the most conceptually interesting compounds in metabolic research.

What is MOTS-c?

MOTS-c — Mitochondrial Open reading frame of the Twelve S rRNA type-c — is a 16 amino acid peptide encoded within mitochondrial DNA rather than nuclear DNA. It belongs to the mitochondrial-derived peptide family, a class whose discovery challenged the assumption that mitochondria simply execute nuclear instructions. Research describes MOTS-c as a retrograde signal: a message sent from mitochondria back to the nucleus, implicating it in AMPK pathway activity, folate-methionine metabolism and the broader coordination of cellular energy status.

Research interest

• Mitochondrial-nuclear signalling — studied as a model for retrograde communication from mitochondria to the nucleus.
• AMPK pathway activity — investigated in research contexts examining cellular energy-sensing and metabolic adaptation.
• Metabolic homeostasis — of interest to groups studying glucose handling and substrate utilisation in preclinical models.
• Exercise and stress physiology — referenced in literature exploring how metabolic stress alters mitochondrial peptide expression.
• Ageing biology — examined in research on mitochondrial function and its relationship to cellular ageing processes.

Interest in mitochondrial-derived peptides has grown quickly, and with it the demand for reliably synthesised reference material. Sequence-verified, batch-tested MOTS-c is essential where the experimental question concerns subtle signalling effects rather than gross responses.

Specifications

• Content: 10 mg of active substance per vial
• Form: Lyophilised powder (vial)
• Purity: Pharmaceutical-grade, batch-tested and lot-traceable
• Presentation: Sealed, tamper-evident single vial
• Storage: -20 °C sealed; 2-8 °C short-term

Handling & storage

Store sealed lyophilised vials at -20 °C for long-term stability; short periods at 2-8 °C are generally tolerated during transit and handling. Keep vials sealed, protected from light and away from moisture and repeated temperature swings. Keep the lyophilised peptide sealed, dry and frozen for long-term stability. Allow vials to equilibrate before opening to prevent condensation. Reconstitute only per the laboratory's validated method with a suitable sterile diluent, then refrigerate, aliquot and avoid repeated freeze-thaw.

Why source from Rogue

• Verified purity — every batch is identity- and purity-tested, with documentation traceable back to the production lot.
• European supply chain — sealed vials, authenticated manufacturing, never grey-market repackaging.
• Cold-aware logistics — protective packaging and fast, tracked dispatch across the EU.
• Discreet handling — plain outer packaging and full order confidentiality, from checkout to doorstep.

For research purposes only. Not a medicinal product. Not for human or veterinary consumption. Intended for qualified laboratory research use only. No statement on this page is a medical claim, and no administration, dosing or protocol guidance is offered or implied.

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